CollaFibR™ for cell and tissue culture
The 3D tissue culture market is an unregulated $1.6B market, growing 15-20% compound annually. The market is focused on the global research community that looks for 3D tissue culture technology that best mimics the biology of complex tissues, increasing the efficiency of drug and vaccine development and decreasing our dependence on animal models. We have developed highly physiologically relevant 2D and 3D extra–cellular matrix environments for cell culture, superior to current available products due to biocompatibility, consistency and stability. Together, these products provide a comprehensive collagen-based platform for life sciences research.
CollaFibR™ 2D cell culture plates
A CollaFibR™ 2D cell culture plate is an aligned, linear array of type I collagen fibers laid on a gel and placed into a traditional cell culture plate. As shown, CollaFibR™ supports cell attachment, directs cellular alignment and elongation, and allows cells to manipulate the collagen environment.
CollaFibR™ 3D Scaffold
A 3D scaffold for cell growth composed of 200 layers of CollaFibR™ in a cross-hatched geometry is shown. This scaffold is assembled layer-by-layer, allowing for control over fiber direction and thickness. Compared to other 3D cell culture products such as Matrigel®, this product has superior batch-to-batch consistency, induces cellular alignment, and has adequate thickness for cell migration.
A multifilament CollaFibR™ fiber is an excellent artificial tendon model. Composed of 30,000 filaments of 600 nm diameter, the CollaFibR™ tendon shows a tensile strength of 250 MPa – 3X higher than native human tendons. While using natural collagen sources, CollaFibR™ can serve as an excellent artificial tendon for both soft tissue repair research and downstream applications in tissue engineering and regenerative medicine. Tendon prototypes are currently being tested by key opinion leaders.
A spider silk prototype with endless potential
Five times stronger than steel while more flexible than rubber, spider silk is one of nature’s most exquisite materials. With nearly endless applications from advanced sutures to ballistic protection, scientists have been trying to replicate spider silk for decades. Using spider silk proteins, the prototype SpidrFibR™ has excellent mechanical properties and shows excellent potential for applications in the green textile industry, and in bio-composite development for aerospace engineering and defence. The SpidrFibR™ prototypes show strength greater than steel and further work is ongoing.